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Curcumin exhibits a broad spectrum of pharmacological properties, including anti-inflammatory, antioxidant, anti-cancer and neuroprotective effects, making it a promising therapeutic candidate for NDs (Tandon et al., 2020)

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Neuroinflammation and the immune system Microglia mediate the immunomodulatory processes in the brain and play a crucial role in the neuroinflammation in PD, leading to chronic activation and releasing of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), which further increase the damage in neurons and promote disease progression 41

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Interestingly, a human cohort study reveals that Helicobacter infection is associated with an increased risk of gallstone disease (Cen et al., 2023)